Appendix 3. Textual analysis of Med2 187
Appendix 3. Textual analysis of Med2 All the academic words in the following text (Wiktor et al. 1999) are highlighted in italics and the assignment of each academic word occurrence to one of six functional categories is indicated by the appearance of the following symbols immediately before each word. Symbol Functional category Metatextual Extratextual Intratextual Scholarly process States of affairs Relations between entities Summary Background There is a high incidence of opportunistic infection among HIV 1 infected patients with tuberculosis in Africa and, consequently, high mortal- ity. We assessed the safety and efficacy of 55trimethoprim sulphamethoxazole 800 mg/160 mg (co-trimoxazole) prophylaxis in prevention of such infections and in decrease of morbidity and mortality Methods Between October, 1995, and April, 1998, we enrolled 771 HIV 1 seropositive and HIV and HIV 2 dually seroreactive patients who had sputum smear positive pulmonary tuberculosis (median age 32 years [range 18-64], median CD4 cell count 317 cells/.L) attending Abidjan’s four largest outpatient tuberculosis treatment centres. Patients were randomly assigned one daily tablet of co-trimoxazole (n 386) or placebo (n 385) 1 month after the start of a standard 6 month tuberculosis regimen. We assessed adherence to study drug and tolerance monthly for 5 months and every months thereafter, as well as rates of admission to hospital Findings Rates of laboratory and clinical adverse events were similar in the two groups. 51 patients in the co-trimoxazole group (13.8/100 person years) and 86 in the placebo group (25.4/100 person years) died (decrease In risk 46% [95%...
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