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Genetics of Bipolar Disorder

Susanne Bengesser and Eva Reininghaus

The high hereditary factor of Bipolar Disorder has been proven by many twin-, adoption- and family-studies already decades ago. Concordance rates between monozygotic twins are even as high as 40-70%. Children of two affected parents have a lifetime-risk of 50-65% to fall ill with Bipolar Disorder, while children with one affected parent show a risk of 25% to get Bipolar Disorder. Therefore psychiatric genetics is highly important to detect the genetic blueprint of Bipolar Disorder to invent prevention strategies, as well as individualized pharmacotherapy and new medication targets. Interestingly top susceptibility genes belong to the ion channel group, growth hormones, clock genes, neurotransmitter systems, Lithium sensitive pathway and other important groups. A detailed and exciting description is given by the authors within this book. Furthermore basic principles of genetics, gene-environment-interactions and genetic overlaps between psychiatric diseases are described to picture the whole painting of Genetics of Bipolar Disorder.


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This book „Genetics of Bipolar Disorder“originated from a very detailed thesis written by Susanne Bengesser under supervision of Eva Reininghaus and myself. Eva Reininghaus received the doctorate of Medicine in 2004 and the doctorate of Medical Science in 2008. Furthermore she did her training as assistant doctor for Psychiatry at the Medical University of Graz/ Department of Psychiatry. Since 2011 she has managed the research group for Bipolar Disorder at the University Hospital of Graz. Furthermore she has been a member of the “ConLiGen-Consor- tium” since 2012. Beside she performed a research period in Toronto/Canada in 2011. Susanne Bengesser studied Medicine and Molecular Biology (Bachelor degree) at the Medical University of Graz and the Karl-Franzens University of Graz (October 2002-April 2010). Then she spent a short research period in Ulm/Germany at the laboratory of the Anatomy department (iPS group) to gain experience in laboratory techniques. Furthermore she started to work as an assis- tant doctor for Psychiatry in Rankweil/Austria (1st of January 2011 until 30th of September 2011) and continued the training in Internal Medicine at the hospital “Elisabethinen” in Linz (1st of Oktober 2011 until 31st of March 2012). Finally she has started to work at the Medical University of Graz/ Department of Psy- chiatry on the 1st of April 2012. Since April she has worked in the outpatient department for Bipolar Disorder and the Bipolar Disorder research group man- aged by Eva Reininghaus. Finally the extension and update of the thesis resulted in this very detailed and...

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